肝切除术后转移到ICU的患者肺部并发症的风险因素和预测模型
Bin Wang1, HanSheng Liang2, HuiYing Zhao1
1Department of Critical Care Medicine, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, China.
BMC surgery
|June 3, 2023
概括
这项研究确定了危急肝切除术患者术后肺部并发症 (PPC) 的关键风险因素,包括年龄,BMI,白蛋白和液体体积. 开发了一种预测性名谱来评估PPC风险,以帮助临床决策.
科学领域:
- 医学研究 医学研究
- 手术瘤学手术瘤学
- 关键护理医学 关键护理医学
背景情况:
- 手术后的肺部并发症 (PPC) 显著影响手术后的患者康复和预后.
- 在接受肝切除术的危急患者中,PPCs的危险因素尚未得到充分确定.
- 肝切除术患者代表了发展PPC的高风险群体.
研究的目的:
- 在肝切除术后的危急成年患者中识别与PPC相关的独立风险因素.
- 在这个患者群体中开发和验证PPCs的预测名录.
主要方法:
- 来自北京大学人民医院的503名患者数据的回顾性分析.
- 使用多变量逻辑回归来确定PPC的独立风险因素.
- 使用接收器运行特征曲线 (AUC) 下的面积和Hosmer-Lemeshow适度测试来评估名图的预测性能.
主要成果:
- 晚年,较高的体重指数,较低的手术前血清白蛋白和第一天重症监护室输液量被确定为PPC的独立风险因素.
- 开发的诺米图表表现出良好的区分能力,AUC为0.713.
- 命名图表显示了良好的校准,表明可靠的PPC发生预测.
结论:
- PPCs是普遍存在的,并与严重的成人肝切除术患者的高死亡率相关.
- PPC的主要预测因素包括晚年,体重指数升高,血清白蛋白低,以及ICU中的大量液体输液.
- 开发的诺米图谱为预测这种脆弱患者群体的PPC提供了有价值的工具.
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