贫血作为COVID-19入院患者疾病进展的风险因素:来自大型多中心队列研究的数据
Nicola Veronese1, Francesco Vladimiro Segala2, Luca Carruba1
1Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro 141, 90127, Palermo, Italy.
Scientific reports
|June 3, 2023
概括
住院COVID-19患者的贫血是常见的,并且与更糟糕的结果有关. 这项研究发现,贫血显著增加了严重疾病和死亡的风险,突出了其在管理COVID-19患者中的重要性.
科学领域:
- 内部医学 内部医学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 贫血是已知的后果和预测呼吸道感染不良结果的预测因素.
- 关于贫血在2019年冠状病毒疾病 (COVID-19) 严重性中的作用的研究有限.
- 贫血可能是预测COVID-19患者结果的重要因素.
研究的目的:
- 评估住院时贫血和严重的COVID-19结局之间的关联.
- 为了确定贫血是否预测COVID-19患者的住院死亡率.
- 为了研究贫血和COVID-19中的炎症性特征之间的关系.
主要方法:
- 从两家意大利医院 (2020年9月至2022年8月) 的成年COVID-19患者回顾性数据收集.
- 贫血定义为血红蛋白<13 g/dL (男性) 和<12 g/dL (女性).
- 考克斯回归分析和倾向性得分匹配用于评估与严重COVID-19和死亡率的关联,以混因素进行调整.
主要成果:
- 在1562名住院COVID-19患者中,贫血患病率为45.1%.
- 贫血患者年龄较大,伴随性疾病较多,炎症标志物较高 (前素,CRP,费里丁,IL-6).
- 在调整后,贫血显著增加了死亡 (HR 2.68) 和严重COVID-19 (OR 2.31) 的风险.
结论:
- 贫血在住院COVID-19患者中很普遍,并与高度的炎症状态有关.
- 入院时的贫血是增加住院死亡率和严重疾病的独立预测因素.
- 临床监测和贫血的管理可能对改善COVID-19结果至关重要.
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