SARS-CoV-2 变种的顺序性肠道进化和进一步传播
Ana S Gonzalez-Reiche1, Hala Alshammary2,3, Sarah Schaefer4
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Nature communications
|June 3, 2023
概括
在免疫功能低下的个体中,持续的SARS-CoV-2感染可能会导致新的变种. 这项研究追踪了一种新的Omicron亚系,BA.1.23,它进化和传播,表现出对免疫的抵抗力.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 持续性严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染发生在免疫功能低下的人群中.
- 记录了SARS-CoV-2的宿主内进化,但不太了解进化的变种的传播和适应.
研究的目的:
- 调查来自持续感染的SARS-CoV-2变种的出现,传播和演变.
- 在长期感染期间出现的新型Omicron亚系 (BA.1.23) 的特征.
主要方法:
- 在8个月内从三个持续感染的个体获得SARS-CoV-2的序列采样和基因组测序.
- 病毒演变的分析,包括尖端蛋白和其他病毒蛋白中的氨基酸替代.
- 使用参与者血清对病毒变异的中和抗性的评估.
主要成果:
- 一个新的Omicron亚系,BA.1.23,出现并在个人之间传播.
- 最初的BA.1.23变种有七个尖端蛋白替代物,并且抵抗免疫血清的中和.
- BA.1.23发生了进一步的进化,在尖和其他蛋白质中积累了额外的突变.
结论:
- 持续的SARS-CoV-2感染可以推动病毒分歧和新型免疫逃避变种的出现.
- 长期感染的患者可以传播这些适应的病毒菌株.
- 迫切需要采取战略,防止长期的SARS-CoV-2复制,并限制脆弱人群中耐药变体的传播.
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