走向虚拟组织学,使用X射线格子干扰计
M Polikarpov1,2, J Vila-Comamala3, Z Wang3,4,5
1Swiss Light Source, Paul Scherrer Institut, 5232, Villigen-PSI, Switzerland. mpolikarpov@ethz.ch.
Scientific reports
|June 3, 2023
概括
两个新的X射线断层扫描系统为乳腺癌诊断提供高分辨率成像. 这些先进的系统提供比传统方法更好的对比度和分辨率,可能有助于他的病理学.
科学领域:
- 医疗成像医学成像
- 生物物理学的生物物理.
- 在瘤学瘤学.
背景情况:
- 乳腺癌的诊断依赖于临床检查,成像和活检,核心针活检是黄金标准.
- 组织病理学使用显微镜进行形态和生化分析,但Z方向分辨率有限.
- 当前的成像技术在乳腺组织样本中的细节解析方面存在局限性.
研究的目的:
- 引入两种新型的高分辨率桌面系统,用于软组织样本的相对比X射线断层扫描.
- 评估这些系统对人类乳腺样本成像的性能.
- 评估这些系统作为临床遗传病理学中补充工具的潜力.
主要方法:
- 开发和实施两相对比X射线断层扫描系统.
- 系统1:经典的Talbot-Lau干扰仪用于人乳样本的ex-vivo成像.
- 系统2:使用Sigray MAAST X射线源与结构性阳极对乳腺样本进行成像,包括在现场进行管道癌的乳腺样本.
主要成果:
- 这两种系统都实现了高分辨率的成像,声素尺寸为5.57微米.
- 证明了Sigray MAAST X射线源系统的适用性,用于在现场成像患有导管癌的人类乳腺样本.
- 与以前的方法相比,实现了更高的分辨率和对比度,使得乳房内部样本特征可以更好地可视化.
结论:
- 基于格的相位对比X射线CT系统可以提供高分辨率,高对比的乳腺组织成像.
- 这些系统有望成为乳腺癌诊断中传统遗传病理学的补充工具.
- 开发的桌面系统提供了一种可行的方法,用于乳腺样本的先进的ex-vivo分析.
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