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易云唐改善了热生成,并减少了与甲状腺功能低下大鼠肠道微生物群相关的炎症
Saeid Khakisahneh1, Xue-Ying Zhang2,3, Song-Yi Han1
1Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814 Siksa-dong, Ilsandong-gu, Goyang-si, 10326, Republic of Korea.
NPJ biofilms and microbiomes
|June 3, 2023
概括
益jung-tang (YJT) 通过调节肠道微生物群来保护大鼠免受低温和炎症. 这种草药配方可能通过向微生物群-肠道-棕色脂肪组织轴来提供一种新的治疗甲状腺功能低下症的方法.
科学领域:
- 系统生物学 系统生物学
- 肠道微生物组研究研究
- 热调节机制 热调节机制
背景情况:
- 草药 (HM) 与肠道微生物组在温度调节中的关系正在引起人们的注意.
- 在温度调节中HM的机制需要进一步阐明.
研究的目的:
- 在甲状腺功能低下症的小鼠模型中,研究益jung-tang (YJT) 对低温,高炎症和肠道失调的作用.
- 探索涉及肠道微生物群和信号通路的潜在机制.
主要方法:
- PTU诱导的甲状腺功能低下的小鼠模型.
- 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式: 给药方式:
- 对肠道微生物群组成的分析.
- 对温度调节和炎症标志物的评估.
- 研究小肠和棕色脂肪组织 (BAT) 中的信号通路.
主要成果:
- 在甲状腺功能低下的老鼠中,YJT保护了抗低温,高炎症和肠道微生物群失生症.
- YJT调节了肠道微生物群,并影响了温度调节和炎症介质之间的信号交换.
- 通过影响肠道TLR4和Nod2/Pglyrp1信号通路,YJT减弱了全身炎症反应.
- YJT促进了BAT热生成,并预防了与其益生菌作用相关的全身炎症.
结论:
- 通过调节肠道微生物群,YJT在治疗甲状腺功能低下相关并发症方面表现出有效性.
- 这些发现支持微生物群-肠道-BAT轴作为甲状腺功能低下症的治疗点.
- YJT可能会提供以全生物为中心的医学方法,专注于宿主和微生物组之间的相互作用.
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