用于故意自我中毒的止痛药的使用:美国中毒中心数据中心趋势
Jummai Apata1, Dinci D Pennap2, Andrew D Mosholder1
1U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Division of Epidemiology 1, Silver Spring, MD, United States.
Journal of psychiatric research
|June 4, 2023
概括
在6-19岁的青少年中,使用常见的止痛药如乙氨基和布洛芬的故意自我中毒增加了,特别是在COVID-19大流行期间. 这种趋势,特别是在女性中,导致了这个年龄组的严重结果.
科学领域:
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 从2000年到2018年,在美国,无处方止痛药的故意自我中毒增加了.
- 在COVID-19大流行期间,心理健康问题升级.
研究的目的:
- 分析2016年至2021年间儿童和成人用乙氨基,阿司匹林,易布洛芬和纳普罗森故意自我中毒的趋势.
- 为了确定疫情前的趋势是否持续并因COVID-19大流行而恶化.
主要方法:
- 利用国家毒药数据系统 (NPDS) 来计算每年涉嫌通过中毒自杀的案例数量.
- 提取了非处方单一成分乙氨基,阿司匹林,布洛芬和纳普罗森的数据.
- 根据年龄,年龄 (儿科和成人) 和性别分析病例,并指出严重程度 (重大影响或死亡).
主要成果:
- 乙氨基和布洛芬是自我中毒病例中最常见的药物.
- 在所有四种止痛药中,年龄在13-19岁的青少年占病例比例最大.
- 女性患病率高于男性 (3:1比率).
- 13至19岁的年龄组中,患有重大临床影响或死亡的病例比例也最高.
- 在6-19岁年龄组中观察到乙氨基和布洛芬中毒的增加趋势,从2020-2021年恶化.
结论:
- 该研究发现,青少年用常见的止痛药,特别是乙氨基和布洛芬自我中毒的增加令人担忧.
- 在COVID-19大流行期间,这种趋势加剧了,特别是在13-19岁的女性中,严重结局的风险更高.
- 调查结果强调了针对青少年心理健康和安全止痛药使用的有针对性的公共卫生干预措施的必要性.
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