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用OVA装载的MSC衍生的外体进行语言下预防,以防止过敏敏感化

Ali Asadirad¹, Ata A Ghadiri², Afshin Amari²

¹Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Cancer, Petroleum and Environmental Pollutants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

International immunopharmacology

|June 4, 2023

概括

中干细胞衍生出异体的语言下给药有效地预防了小鼠的过敏性喘. 这种预防性治疗调节了免疫反应,减少了过敏敏感和炎症.

科学领域:

免疫学免疫学免疫学
再生医学是一种再生医学.
过敏研究研究过敏

背景情况:

过敏性喘是一种慢性呼吸道疾病,其特点是气道炎症和过度反应.
介质干细胞 (MSC) 衍生的外生体显示出免疫调节和治疗交付的前景.
舌下注射提供了一种非侵入性途径,用于输送治疗剂.

研究的目的:

评估脂肪组织衍生的MSC外体的免疫调节和传递潜力.
评估MSC衍生的外体体作为预防方案的潜舌服药的疗效.
在卵胺 (OVA) 诱导的过敏喘小鼠模型中研究这些影响.

主要方法:

在三周内,Balb/c小鼠接受了OVA丰富的MSC衍生的外体的预防性语言下剂量.
过敏性喘是通过通过腹腔内和气溶给药的OVA敏感化诱导的.
通过通过ELISA测量总细胞,鼻洗液中的乙氨基基,肺组织病理学,脏细胞细胞因子分泌 (IFN-γ,IL-4,TGF-β) 和血清OVA特异性IgE水平来评估免疫反应.

主要成果:

语言下MSC衍生的外体显著降低了OVA特异性IgE水平和IL-4的产生.
观察到TGF-β水平升高,表明转向免疫耐受性.
组织病理学分析显示,肺组织的炎症有限,鼻洗液中的细胞数量正常.

结论:

用OVA丰富的MSC衍生的外体的预防性语言下给药有效调节了免疫反应.
这种疗法抑制了过敏性OVA敏感性,证明了作为过敏性喘新治疗策略的潜力.

关键词:

交付系统的交付系统.外基因组是外基因组中的一个.介质细胞干细胞 (MSC)预防预防预防下语言路线是次语言路线.

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