运动训练对长期COVID患者呼吸障碍的有效性:一个随机对照的多中心试验
Christophe Romanet1, Johan Wormser1, Audrey Fels2
1Department of Intensive Care, Groupe Hospitalier Paris Saint Joseph, Paris, France.
Annals of physical and rehabilitation medicine
|June 4, 2023
概括
运动训练康复在COVID-19相关的急性呼吸困扰综合征 (CARDS) 和持续症状的患者中显著降低呼吸困扰. 与标准物理治疗相比,这种90天的干预改善了生活质量.
科学领域:
- 肺部病理学 肺部病理学
- 密集护理医学 密集护理医学
- 康复医学 康复医学 康复医学
背景情况:
- 与COVID-19相关的急性呼吸窘迫综合征 (CARDS) 是SARS-Cov-2感染的严重并发症,需要密集护理.
- 长期的COVID可以表现为持续的呼吸道症状,感染后长达一年,需要康复.
研究的目的:
- 评估运动训练康复 (ETR) 在改善呼吸不良和与健康相关的生活质量方面在 CARDS 后持续呼吸不适的人群中的有效性.
- 在这个患者群体中,将ETR与标准物理治疗 (SP) 进行比较.
主要方法:
- 一个多中心,随机对照试验,涉及至少3个月前出院的成年人,在mMRC尺度上有CARDS和呼吸障碍得分>1.
- 参与者被随机分配,接受90天的ETR或SP.
- 主要结局:通过多维呼吸障碍概况 (MDP) 测量呼吸障碍;次要结局:mMRC和SF-12得分.
主要成果:
- 60名参与者被随机选择 (27名为ETR,33名为SP).
- 平均MDP得分在ETR后比SP低42% (-18.61差异;p<10-4).
结论:
- 九十天的ETR显著改善了在CARDS后经历持续性呼吸困难的患者的呼吸困难得分.
- 与标准物理治疗相比,ETR提供了一种优越的治疗选择,用于管理与标准物理治疗相比,心脏病后的呼吸连续症.
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