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Updated: Jul 28, 2025

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
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与心肌病相关的变体改变了α-actinin-2actin-binding域的结构和功能

Alexandra E Atang1, Robyn T Rebbeck2, David D Thomas2

  • 1Department of Chemistry, Oakland University, Rochester, MI, 48309-4479, USA.

Biochemical and biophysical research communications
|June 4, 2023
PubMed
概括

在ACTN2的遗传变异影响心肌功能. 这项研究揭示了α-actinin-2中的特定突变如何改变actin结合,从而导致诸如高性心肌病等心肌病.

关键词:
动蛋白结合性 动蛋白结合性一个圆形的二重化.蛋白质折叠过程中的蛋白质折叠热变质化是一种热性变质化.

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