尼古丁胺胺单核酸通过调节肠道微生物群来改善阿尔茨海默氏症
Xiaodong Zhao1, Mengmeng Kong1, Yilin Wang2
1College of Biological Science and Technology, University of Jinan, Jinan, 250022, China.
Biochemical and biophysical research communications
|June 4, 2023
概括
尼古丁胺胺单核酸 (NMN) 改变了阿尔茨海默氏病 (AD) 的小鼠的肠道微生物群,增加了有益的细菌. 这表明NMN是通过调节肠-大脑轴来治疗AD的潜在治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿尔茨海默病 (AD) 是一种进展性神经退行性疾病.
- 肠-大脑轴 (GBA) 和与之相关的微生物群在中枢神经系统 (CNS) 疾病中起作用.
- 尼古丁胺胺单核酸 (NMN) 是NAD+的前体,在减少AD大脑病理方面表现有前途.
研究的目的:
- 在阿尔茨海默氏病 (AD) 鼠标模型中研究NMN对肠道微生物群组成的影响.
- 探索NMN治疗与阿尔茨海默病患者肠道微生物群体变化之间的关系.
- 评估NMN在调节肠道健康方面的潜力及其对AD的影响.
主要方法:
- 使用APP/PS1转基因小鼠作为AD模型.
- 进行NMN治疗16周.
- 使用16S核糖体RNA (rRNA) 高通量测序分析便样本,以分析肠道微生物群.
主要成果:
- 在AD小鼠中,NMN显著改变了肠道微生物社区结构.
- NMN治疗增加了短链脂肪酸 (SCFA) 生产细菌的相对丰度,包括Lactobacillus和Bacteroides在属级.
- 这些变化表明NMN保护肠道健康,并可能改善AD病理.
结论:
- 在AD小鼠中,NMN调节肠道微生物群组成.
- NMN对肠道细菌的影响突显了它作为AD治疗策略的潜力.
- 肠道微生物群是AD病理学的关键因素,为未来的研究和治疗提供了途径.
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