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不一致的皮肤刺测试对白同类树的过敏可能是由于交叉反应过敏原或技术错误造成的
Caroline Beutner1, Christian Wrobel2, Tobias Dombrowski2
1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
International archives of allergy and immunology
|June 4, 2023
概括
减少过敏性鼻炎 (AR) 的皮肤刺探测试 (SPT) 中的过敏原可能会错误诊断. 对于树,树和树花粉的不一致结果凸显了对AR患者进行全面测试和分子诊断的需要.
科学领域:
- 过敏原免疫疗法免疫疗法
- 免疫学 免疫学 免疫学
- 呼吸系统药物 呼吸系统药物
背景情况:
- 皮肤刺伤测试 (SPT) 是诊断过敏性鼻炎 (AR) 的标准.
- 有一场关于减少SPT面板中的过敏原的辩论,特别是对交叉反应的树,树和花粉的辩论.
- 目前的临床指南还没有纳入这些建议的减少.
研究的目的:
- 为了研究一个亚组的过敏性鼻炎患者与不一致的SPT结果在树,树和树之间.
- 评估潜在减少的SPT小组对诊断的影响.
主要方法:
- 研究了69名AR患者,并对树,树和树进行不一致的SPT结果.
- 执行了SPT,评估了临床相关性,并分析了血清学参数,包括总和特定IgE.
- 包括针对白树,树,树和相关分子 (Bet v1,Bet v2,Bet v4) 的特定IgE测试.
主要成果:
- 超过一半的患者有负面的树SPT,但对树/树有积极的结果.
- 87%的研究小组对其他植物过敏原过敏.
- 如果将SPT仅限于树,这将使该子组中52.2%的诊断错过.
- 对白花粉提取物 (30.4%) 的血清敏感性不同于特定IgE到Betv1 (18.8%).
结论:
- 对同类花粉的不一致的SPT结果可能来自交叉反应或错误.
- 一个减少的SPT面板可能会忽视显著的过敏敏感性.
- 对于症状一致且SPT结果不明确的患者,重复测试和分子诊断对于准确的AR诊断至关重要.
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