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美国扩散型大B细胞淋巴瘤的老年患者中精神健康障碍和生存率:基于人口的研究
Thomas M Kuczmarski1, Angela C Tramontano2, Lee Mozessohn3
1University of Washington, Fred Hutchinson Cancer Center, Seattle, WA, USA.
The Lancet. Haematology
|June 4, 2023
概括
以前存在的抑郁和焦虑会使扩散性大B细胞淋巴瘤 (DLBCL) 患者的生存率恶化. 早期心理健康查和管理对于改善DLBCL幸存者的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 精神病学是一个精神病学.
背景情况:
- 心理健康障碍可能会对癌症患者的生活质量和生存产生负面影响.
- 关于精神健康障碍对扩散型大B细胞淋巴瘤 (DLBCL) 的生存影响的数据有限.
研究的目的:
- 评估先前存在的抑郁,焦虑或两者对美国老年患者诊断为DLBCL的存活率的影响.
主要方法:
- 利用SEER-Medicare数据库来识别被诊断患有DLBCL的67岁以上的患者 (2001-2013).
- 在DLBCL诊断之前使用计费索赔确定了先前存在的抑郁症/焦虑症.
- 使用考克斯比例分析,对临床和社会人口统计因素进行调整,比较了5年整体和淋巴瘤特异性生存率.
主要成果:
- 在13,244名DLBCL患者中,15.8%的患者先前患有抑郁症,焦虑症或两者兼而有之.
- 患有这些精神健康障碍的患者的5年整体存活率 (27.0%对37.4%) 和淋巴瘤特异性存活率显著降低.
- 仅抑郁症就与最差的生存结果有关 (HR为整体存活1.37,为淋巴瘤特异性存活1.37).
结论:
- 以前存在的抑郁症,焦虑症或两者都会对DLBCL患者的预后产生负面影响.
- 强调需要对DLBCL患者进行普遍心理健康查.
- 改善这些并发症的管理可能会提高DLBCL患者的存活率.
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