不同的NAD的急性作用
Xiangyu Li1, Hong Yang2, Han Jin2
1Bash Biotech Inc, 600 West Broadway, Suite 700, San Diego, CA, 92101, USA; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Guangzhou Laboratory, Guangzhou, 510005, China.
Free radical biology & medicine
|June 4, 2023
概括
结合代谢激活剂 (CMA) 与尼古丁胺 (Nam),尼古丁胺单核酸 (NMN) 或尼古丁胺核酸 (NR) 有效地提高了NAD+水平. 这些前体有望改善代谢状况,而不会产生冲等不良影响.
科学领域:
- 代谢生物化学 代谢生物化学
- 人类临床研究研究.
- 营养学研究 营养学研究
背景情况:
- NAD+和谷氨的前体被用于管理像NAFLD和糖尿病这样的代谢障碍.
- 组合代谢激活剂 (CMA) 旨在改善代谢健康.
- 了解CMA中不同NAD+前体的有效性和安全性至关重要.
研究的目的:
- 评估含有NAD+前体的六种不同的CMA配方的安全性和急性影响.
- 分析各种NAD+前体对血代谢学的影响.
- 为了确定最佳的CMA配方来提高NAD+水平.
主要方法:
- 一天,双盲,安慰剂控制的人类临床研究.
- 用6种不同的CMA与1g各种NAD+前体一起给药.
- 血样本的全球代谢学分析.
主要成果:
- 在没有直接的NAD+前体的情况下,NAD+救援途径是通过CMA增加NAD+水平的主要途径.
- 尼古丁胺 (Nam) 纳入CMA最有效地增强了NAD+产品,其次是尼亚 (NA),尼古丁胺 рибоoside (NR) 和尼古丁胺 mononucleotide (NMN).
- 尼雅 (NA) 给药导致脸红和脂和胆红素水平的潜在风险变化.
结论:
- 含有尼古丁胺 (Nam),尼古丁胺单核酸 (NMN) 或尼古丁胺核酸 (NR) 的CMA有效提高NAD+水平.
- 这些配方显示出改善代谢条件的潜力.
- 在这项研究中,无冲洗的氨酸 (FFN) 没有显示出显著的NAD+增强效应.
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