冲击门:针对动态紧密交叉点的新方法,以改善药物输送
Isabela Ramirez-Velez1, Brian Belardi1
1McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, United States.
Advanced drug delivery reviews
|June 4, 2023
概括
生物学家面临着穿透组织的挑战,这限制了他们的有效性. 针对动态紧密结的新策略为改善跨越生物障碍的药物输送提供了有希望的方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
- 药物输送系统 药物输送系统
背景情况:
- 生物制剂在临床上越来越多地使用,但它们的有效性受到通过胃肠道和血脑屏障等生物屏障的组织透率较低的限制.
- 宏分子药物以其体积,高分子量和水友性质为特征,努力穿透这些障碍.
- 细胞膜和上皮层内的细胞间紧密结合是阻碍药物吸收的关键亚细胞结构.
研究的目的:
- 审查针对紧密交叉点的新策略,无论是直接还是间接.
- 探索如何操纵紧结相互作用可以增强宏分子药物的输送.
- 突出针对紧密交叉点的潜力,为准确药物输送的新时代.
主要方法:
- 关于紧结动态和药物输送的最新科学文献的综述.
- 对直接和间接方法的分析,以准紧密的交叉点.
- 讨论紧接点操纵对宏分子药物运输的影响.
主要成果:
- 紧密的结口,曾经被认为是不可穿透的,现在被理解为动态和可准的结构.
- 新兴的方法证明了调节药物输送的紧接口透性的潜力.
- 针对紧密的十字路口提供了一个可行的策略,以克服生物药物输送中的一个主要障碍.
结论:
- 紧密结点向代表了在克服生物药物穿透组织的挑战方面取得的重大进展.
- 对紧密结相互作用的操纵有望为开发更有效的精确药物递送系统提供希望.
- 对这些动态结构的进一步研究将对实现先进疗法的全部潜力至关重要.
相关概念视频
01:29Tight Junctions
5.4K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
5.4K
01:16Drug Delivery: Overview
329
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
329
01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
604
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
604
01:22Drug Delivery: Miscellaneous Routes
408
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
408
01:24Cellular Membranes and Drug Transport
689
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
689
01:17Pore Transport and Ion-Pair Transport
525
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
525