不控制喘的多种表现增加了严重COVID-19的风险
Stina Selberg1, Johanna Karlsson Sundbaum2, Jon R Konradsen3
1Department of Public Health and Clinical Medicine, Division of Medicine/the OLIN-unit, Umeå University, Umeå, Sweden.
Respiratory medicine
|June 4, 2023
概括
失控的喘增加了COVID-19的严重性风险. 多重喘症状和肥胖症显著提高了严重COVID-19结果的危险性,需要对患者进行仔细评估.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 控制喘对于预测严重的COVID-19结果至关重要.
- 在病毒感染的背景下,不受控制的喘存在独特的风险.
研究的目的:
- 调查控制不下的喘和严重的COVID-19的临床特征之间的关联.
- 评估多种不受控制的喘症状对COVID-19严重性的影响.
主要方法:
- 从2014年至2020年利用瑞典国家气道登记 (SNAR),确定了24533名患有非控制性喘的成年患者 (喘控制测试[ACT] ≤19).
- 将SNAR数据与国家登记处联系起来,以确定221名患有严重COVID-19的患者.
- 采用Poisson回归分析,逐步评估不受控制的喘表现 (ACT ≤15,频繁恶化,先前住院).
主要成果:
- 肥胖成为两性中严重COVID-19最强的独立风险因素,在男性中更为明显.
- 与对照组相比,患有严重COVID-19的患者更频繁地表现出不控制喘的多种表现:一种 (45.7%),两种 (18.1%),三种 (5.0%).
- 越来越多的不受控制的喘症状与严重COVID-19的显著更高风险相关 (RR 1.49至2.96),根据性别,年龄和BMI进行调整.
结论:
- 控制不下的喘和肥胖的多种表现是评估COVID-19风险的关键因素.
- 这些因素大大增加了严重COVID-19结果的可能性,强调了全面风险评估的必要性.
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