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互联网游戏障碍中的大脑结构变化:专注于中皮层临性多巴胺作用系统

Ming-Yuan Tian¹, Xin-Yi Zhou², Xiao-Yuan Liao²

¹Department of Psychiatry, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Nuclear Industry 416 Hospital, the 2nd Affiliated Hospital of Chengdu Medical College, Chengdu, China.

Progress in neuro-psychopharmacology & biological psychiatry

|June 4, 2023

概括

互联网游戏障碍 (IGD) 与大脑关键区域的灰质体积增加有关,特别是在中皮层临性多巴胺系统内. 这些变化与IGD患者的游戏嗜好和自我控制能力下降有关.

科学领域:

神经科学是一个神经科学.
神经成像是一种神经成像.
精神病学是一个精神病学.

背景情况:

互联网游戏障碍 (IGD) 是一个越来越令人担忧的问题,具有重大公共卫生影响.
了解IGD的神经生物学基础对于开发有效干预措施至关重要.
中皮层临床多巴胺基系统在奖励处理和成中发挥着关键作用.

研究的目的:

研究IGD患者的灰质体积 (GMV) 和白质体积 (WMV) 差异.
专门研究IGD.中中皮层临性多巴胺系统内的变化.
探索这些结构性大脑变化与IGD的临床症状 (如渴望和自我控制) 之间的联系.

主要方法:

基于voxel的形态测量 (VBM) 分析被用来比较IGD和健康对照对象之间的GMV和WMV.
感兴趣的区域 (ROI) 分析侧重于中皮层临床多巴胺系统的子区域.
进行了统计分析,以确定GMV/WMV与渴望和自我控制的临床措施之间的相关性.

主要成果:

与对照人群相比,患有IGD的个体在双边尾部和左侧核 (NAc) 中表现出增加的GMV,并在下额叶中增加WMV.
投资回报分析证实,在双边尾状细胞中GMV更大,在IGD中左NAc核心更大,在中皮层膜系统中没有显著的WMV变化.
轨道前皮层 (OFC) 和前胰岛的GMV与IGD的游戏欲望和自我控制缺陷有显著的关联.

结论:

互联网游戏障碍的特点是,在中皮层临性多巴胺系统内,GMV发生变化,但不是WMV.
在中皮层临系统中的这些GMV变化可能是IGD患者自我控制能力受损和渴望增加的基础.
神经成像的发现为神经机制提供了有价值的见解,这些神经机制有助于IGD的发展和维持.

关键词:

渴望的渴望渴望的渴望互联网游戏障碍互联网游戏障碍中皮层临床多巴胺基系统自制是一种自我控制.基于voxel的形态测量方法

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