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大麻二醇的基因毒性评估

Rayetta G Henderson¹, Brian T Welsh², Kristen R Trexler³

¹ToxStrategies, Inc., Wilmington, NC, 28411, USA.

Regulatory toxicology and pharmacology : RTP

|June 4, 2023

概括

用三项测试评估了大麻素 (CBD) 的基因毒性潜力. 纯CBD分离物在体外或体内没有表现出任何基因毒性危险,这表明消费者健康使用的安全性.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
遗传学是一个遗传学.

背景情况:

消费者对大麻 (CBD) 的健康兴趣很高,但安全性数据,特别是基因毒性,是有限的.
现有研究往往缺乏质量,原因是不纯粹的试验材料或低于最佳的研究设计,造成监管数据缺口.

研究的目的:

为了全面评估纯CBD分离物的基因毒性潜力.
为了解决监管机构和消费者对CBD安全性的数据差距.

主要方法:

根据经合组织的指导方针,进行了三项标准基因毒性测定.
试验室内测试包括微生物逆变异试验 (Ames试验) 和在人体细胞中试验室内微核试验.
在老鼠身上进行了体内微核试验,对CBD及其代谢物进行了生物分析.

主要成果:

在体外微生物逆转基因突变试验中,CBD分离物的基因毒性测试结果为负,高达5000μg/盘.
在人体细胞中的体外微核试验中,CBD分离物的检测结果为阴性,高达10-11μg/mL.
在小鼠的体内微核试验中,CBD分离物在高达1000mg/kg-bw/d的剂量下呈阴性,已确认与剂量相关的血暴露.

结论:

进行的基因毒性测定表明,纯CBD分离物不太可能构成基因毒性危险.
这些发现为关于CBD使用的公共领域提供了关键的安全数据.
这项研究支持CBD在消费者健康应用中的安全性.

关键词:

艾姆斯·艾姆斯 (Ames Ames) 是一个在这里,我们可以看到CBD CBD CBD CBD.大麻二醇 (Cannabidiol) 是一种基因毒性基因毒性微核是微核中的一个.致变性致变性致变性

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