高胆固醇和缺血性心脏病的负担在一个老龄化的世界
Angela Pirillo1, Giuseppe Danilo Norata2
1Center for the Study of Atherosclerosis, E. Bassini Hospital, Cinisello Balsamo, Milan, Italy.
Pharmacological research
|June 4, 2023
概括
心血管疾病仍然是全球主要的死亡原因. 高胆固醇血治疗和意识的差异,特别是高收入和低收入国家之间的差异,导致持续的缺血性心脏病死亡.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD),特别是缺血性心脏病 (IHD),是全球死亡和残疾的主要原因.
- 高胆固醇血症是IHD的主要风险因素,需要有效的管理策略.
- 尽管降胆固醇药物取得了进展,但在全球范围内,失脂症意识和医疗保健支出方面的差异仍然存在.
研究的目的:
- 分析血胆固醇水平的全球趋势及其与缺血性心脏病 (IHD) 死亡率的关联.
- 调查高胆固醇血管理和全球不同经济层面的结果之间的差异.
- 确定受这些差异影响最大的特定人口群体,如妇女和老年人.
主要方法:
- 在过去三十年中,对心血管疾病死亡率和血胆固醇水平的全球健康数据的分析.
- 按国家收入水平对数据进行分层,以评估健康结果中的经济差异.
- 检查与高LDL-C水平相关的特定年龄和性别的死亡率数据.
主要成果:
- 全球血胆固醇水平在30年内没有显著变化,但高收入国家改善了脂质谱,导致IHD死亡率降低.
- 低收入国家没有看到类似的改善,有些国家在IHD死亡率上升.
- 高LDL-C相关的IHD死亡不成比例地影响60岁及以上的个人,观察到基于收入的变化.
结论:
- 在管理高胆固醇血症方面存在显著的全球差异,直接影响IHD死亡率.
- 经济状况是成功降低胆固醇相关心血管疾病负担的关键决定因素.
- 需要有针对性的干预措施来弥合高胆固醇血治疗的差距,重点关注包括妇女和老年人在内的弱势群体.
更多相关视频
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.3K
09:06Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
8.4K
相关概念视频
01:17Ischemic Heart Disease: Overview
1.4K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.4K
01:26Atherosclerosis III: Management
15
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
15
01:26Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
01:30Coronary Artery Disease I: Introduction
33
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
33
01:26Coronary Artery Disease IV: Preventive Measures
25
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
25
01:30Atherosclerosis I: Introduction
13
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
13