间歇性肺部疾病与肺癌切除后的结果之间的关联
Andrea L Axtell1, Elizabeth A David2, Mark I Block3
1Division of Thoracic Surgery, Massachusetts General Hospital, Boston, Massachusetts.
The Annals of thoracic surgery
|June 4, 2023
概括
间歇性肺病 (ILD) 显著增加了肺癌手术后死亡和并发症的风险. 这一发现甚至适用于其他正常肺功能患者,强调ILD是手术结果的关键因素.
科学领域:
- 肺部医学 肺部医学
- 胸部外科手术 胸部外科手术
- 在瘤学瘤学.
背景情况:
- 间歇性肺病 (ILD) 与更高的肺癌率和术后并发症风险增加有关.
- 了解ILD对肺切除结果的影响对于患者管理至关重要.
研究的目的:
- 调查间歇性肺病 (ILD) 对非小细胞肺癌肺切除后全国范围的结局的影响.
主要方法:
- 胸部外科医生协会一般胸部外科数据库 (2009-2019) 的回顾性分析.
- 与ILD和无ILD患者之间的基线特征和术后结果的比较.
- 多变量后勤回归用于确定死亡率,ARDS和复合发病率/死亡率的风险因素.
主要成果:
- 在为非小细胞肺癌进行肺切除的患者中,有1.5%患有ILD.
- 患有ILD的患者吸烟,肺高血压,扩散能力受损和亚叶切除率较高.
- ILD与术后死亡率 (5.1%对1.2%),ARDS (1.9%对0.5%) 和复合发病/死亡率 (13.2%对7.4%) 的显著增加有关.
结论:
- 间歇性肺病 (ILD) 是肺癌切除后手术死亡率和发病率的重要风险因素.
- 与ILD相关的风险增加即使在肺功能正常的患者中仍然存在.
- 这些发现强调了在手术规划和肺癌患者的风险评估中考虑ILD的重要性.
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