通过不同类型的葡萄球菌对StaphylococcusAureus的异质调控Epidermidisagr类型在无氧性皮肤炎中的类型
Yuan Zhou1, Xiaoqiang Xu2, Yang Liu3
1Department of Allergy and Rheumatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
The Journal of investigative dermatology
|June 4, 2023
概括
具有特定辅助基因调节器 (agr) 类型的 Staphylococcus epidermidis (S. epidermidis) 菌株显示出对亚托皮性皮炎 (AD) 的保护作用. 这些S. epidermidis菌株干扰金黄色葡萄球菌的毒性,减少皮肤炎症.
科学领域:
- 微生物学 微生物学
- 皮肤病学 皮肤病学
- 基因组学就是基因组学.
背景情况:
- 皮肤共生性葡萄球菌 (Staphylococcus epidermidis) 在皮肤炎症中起作用,但其在亚托皮炎 (AD) 中的特定功能和机制尚不清楚.
- 了解S. epidermidis菌株变异对于阐明它在AD病变发生过程中的作用至关重要.
研究的目的:
- 调查从患有AD的儿科患者中分离的S. epidermidis菌株的功能基因异质性.
- 为了确定特定的S. epidermidis亚格类型及其对S. aureus毒性和AD类皮肤炎症的影响.
主要方法:
- 来自AD患者的S. epidermidis菌株的全基因组测序.
- 对辅助基因调节 (agr) 操作子变异的分析.
- 在体外功能测定和皮肤炎症的小鼠模型.
主要成果:
- 在AD分离物中观察到S. epidermidis的功能基因在菌株水平上的显著异质性.
- S. epidermidis agr类型I和IV,但不是II和III,抑制了S. aureus病毒性因子表达和表皮殖民.
- 在小鼠模型中,S. epidermidis agr类型I和IV减弱了皮肤炎症.
结论:
- 在AD中划定了S. epidermidis的菌株特异性基因组特征.
- 在S. epidermidis agr类型IV和S. aureus之间进行的定数感应干扰为AD提供了潜在的治疗策略.
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