用于软组织肉瘤的CivaSheet®:一个单一机构的经验
Crystal Seldon1, Julie G Grossman2, Gautam Shrivastava1
1Department of Radiation Oncology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL.
Brachytherapy
|June 4, 2023
概括
一种可植入的-103装置CivaSheet显示了通过提供向辐射来治疗软组织肉瘤 (STS) 的潜力. 初步结果显示,局部复发率为40%,在某些情况下出现4级并发症.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医疗器械 医疗器械
背景情况:
- 软组织肉瘤 (STS) 提出了治疗挑战,特别是在已经达到最大辐射耐受度的患者中.
- 术内辐射疗法 (IORT) 提供了一种在手术期间提供向辐射剂量的方法.
- 103 (Pd-103) 是一种放射性同位素,因其剂量计特性而用于胸膜疗法.
研究的目的:
- 评估使用CivaSheet的初始临床经验和结果,CivaSheet是一种使用ladium-103.3的植入式术内放射治疗设备.
- 评估CivaSheet在手术切除软组织肉瘤患者的安全性和有效性.
- 确定与CivaSheet安置相关的本地复发率和并发症概况.
主要方法:
- 在2018年1月至2019年12月期间,对通过外科切除和CivaSheet安置治疗的STS患者进行了回顾性图表审查.
- 含有-103的CivaSheet设备,在5毫米的深度下,平均提供了47 Gy的辅助辐射剂量.
- 患者数据包括瘤位置,大小,手术重建方法,局部复发和并发症.
主要成果:
- 在9名STS患者身上植入了10张CivaSheets,平均随访时间为27个月.
- 瘤的位置各不相同,包括尾,胸部,沟和下肢,平均瘤大小为7.6厘米.
- 观察到40%的局部复发率. 三名患者出现了4级并发症,需要移除设备,特别是在先前进行放射和片重建的情况下. 肢体瘤显示高4级不良事件的高率.
结论:
- CivaSheet代表了一种用于STS患者手术期间辐射增强的新方法.
- 虽然显示出潜力,但观察到的局部复发和并发症率需要进一步调查.
- CivaSheet可能是传统支臂治疗方法的可行替代品,但仔细的患者选择和监测至关重要.
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