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Developing a Rat Model for Bipolar Disorder
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在1261名双相情感障碍患者中,快速循环的特征
Alessandro Miola1,2, Leonardo Tondo3,4,5, Marco Pinna6,7
1Department of Psychiatry, University of Padova, Padua, Italy.
International journal of bipolar disorders
|June 4, 2023
概括
双极性障碍 (BD) 的快速循环影响9.36%的患者,特别是女性和BD2.2患者. 虽然与更高的复发率有关,但它通常涉及较短的情节,可能与抗抑郁药的使用有关.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 快速循环 (RC),定义为≥4次/年,是双极性障碍 (BD) 的一个公认但不太了解的方面.
- 以前的研究表明,RC与较差的治疗结果有关,但其与特定BD亚型的长期关联和关系尚不清楚.
研究的目的:
- 在一大群双相情感障碍患者中调查快速循环的患病率和临床相关性.
- 检查快速循环与诊断亚型 (BD1与BD2) 的关联,人口统计因素,疾病特征和治疗反应.
主要方法:
- 一组1261名双相情感障碍患者被评估是否有快速循环史,并被前性地跟踪了几年.
- 描述性和临床特征,包括发作率,病期,治疗,自杀风险和家族病史,在快速循环和没有快速循环的患者之间进行了比较.
- 多变量回归分析被用来确定快速循环的独立预测因素.
主要成果:
- 在9.36%的BD患者中发现了快速循环,在女性中更常见,BD2比BD1.
- RC-BD患者每年复发率高3.21倍,但没有住院,自杀风险更高,并且更有可能具有循环性气质.
- 独立的RC预测因素包括年龄较大,情绪转换与抗抑郁药,BD2诊断,和更高的年度病例数;然而,大多数以前的RC患者有<4次/年前性.
结论:
- 在BD中,RC的终身风险为9.36%,女性,老年人和BD2.2的可能性更高.
- RC与复发的增加有关,特别是抑郁症,但发作可能更短,影响整体患病时间更少.
- 抗抑郁症并非始终持续,其与不良结果的关联是可变的,可能受抗抑郁药使用的影响.
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