对于具有低发作反应的高能效千赫兹频率神经块的时空空间参数
Edgar Peña1, Nicole A Pelot1, Warren M Grill2,3,4,5
1Department of Biomedical Engineering, Duke University, Room 1427, Fitzpatrick CIEMAS, 101 Science Drive Campus Box 90281, Durham, NC, 27708, USA.
Journal of neuroengineering and rehabilitation
|June 4, 2023
概括
千赫兹频率 (KHF) 神经阻断显示出治疗疾病的前景. 使用复合波形和电极几何学来优化KHF信号,可以减少能源需求,并最大限度地减少不必要的神经刺激,以获得更安全,更有效的神经阻塞疗法.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 医疗器械 医疗器械
背景情况:
- 电神经传导阻断为疾病治疗提供可逆的神经失活.
- 高能耗要求和不需要的神经刺激极限千赫兹频率 (KHF) 神经阻塞效率.
- 对参数优化 (频率,电极几何,波形) 的有限理解阻碍了KHF神经块的翻译.
研究的目的:
- 为了评估大鼠骨神经中的千赫兹频率 (KHF) 神经阻塞.
- 研究不同频率,电极几何形状和波形形状对神经块参数的影响.
- 开发和评估一种用于构建复合KHF信号以优化神经阻塞的新方法.
主要方法:
- 在老鼠神经中测试了KHF神经块,跨频率 (5-60 kHz),电极几何形状 (单极,双极,三极) 和波形状.
- 利用一种基于里埃的新方法来构建复合信号,系统地探索KHF波形设计.
- 分析了与信号参数和电极配置相关的阻断值和发作响应.
主要成果:
- 最低的有效阻断频率 (5-16 kHz) 并不是最节能的.
- 单极电极和三极电极证明了神经阻断的最低功率要求,单极电极需要最少的电流.
- 复合信号,特别是那些具有基本和二正弦形,减少阻断值和开始响应的复合信号,取决于相位和振幅,特别是单极和三极电极.
结论:
- 获得了关于KHF神经阻断频率边界的阻断值和发病反应的新见解.
- 在KHF神经块中证明了空间 (电极几何) 和时间 (频率,波形) 参数之间的相互作用.
- 优化的波形形状可以减少能源消耗和不良发作反应,克服以前的权衡.
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