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一个T细胞激活瘤有机平台用于胰腺癌免疫疗法

Zhuolong Zhou1, Kevin Van der Jeught1, Yujing Li1

  • 1Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|June 5, 2023
PubMed
概括

新的胰腺癌有机体模型使药物发现成为可能. 将表观遗传抑制剂与免疫疗法结合起来,通过增强瘤微环境中的T细胞活性,显著增强了抗瘤效应.

关键词:
表观遗传抑制剂 表观遗传抑制剂高通量药物查屏幕的使用免疫疗法 免疫疗法胰腺管道腺癌瘤患者获得的有机原体瘤抗原呈现的表现.瘤的有机体是有机体.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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