在用于新型全身抗癌治疗的肠道制剂中,选择的微生物的活力
Jannik Almasi1, Laura Knoll1, Judith Thiesen1
1Department of Pharmacy, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
概括
致病微生物在大多数准备使用的亲肠道癌症疗法中仍然是可行的. 严格的无菌条件和缺乏抗菌活性对于赋予这些制剂的保质期至关重要.
科学领域:
- 制药微生物学 制药微生物学
- 癌症治疗方法 癌症治疗方法
- 医院药房实践 医院药房实践
背景情况:
- 亲肠道药物的无菌制备需要了解微生物的生存能力.
- 微生物可以在肠道药物中保持生命力,从而影响到保质期的确定.
- 评估微生物生存能力对于用于癌症治疗的亲肠道药物至关重要.
研究的目的:
- 为了评估20种准备注射的肠道抗癌制剂中的4种致病微生物的生存能力.
- 评估医院无菌制备的亲肠道药物中的微生物存活率.
主要方法:
- 在20种亲肠道抗癌药物中注射金黄色葡萄球菌,Pseudomonas aeruginosa,Enterococcus faecium或Candida albicans.
- 在37°C化接种样本,并在多个时间点 (0-144小时) 计数殖民地形成单位 (CFU).
主要成果:
- 在大多数溶液中观察到P. aeruginosa的CFU计数增加和E. faecium和S. aureus的稳定/增加计数.
- 阿扎西蒂丁,皮克桑特龙和文弗卢宁表现出细菌静止/杀菌作用.
- 在大多数溶液中,除了含有尼沃卢马布和皮克桑的溶液外,Candida albicans仍然是可行的.
结论:
- 致病微生物在大多数经过测试的亲肠道抗癌制剂中保持了生存能力.
- 医院药房必须保持严格的无菌条件.
- 在确定准备使用的亲肠道制剂的保质期时,应考虑缺乏抗菌活性.
相关概念视频
01:29Microorganisms in Medicine and Therapeutics
73
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
73
01:29Key Techniques in Microbiology
130
Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
130
02:49Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
01:29Drug Delivery: Parenteral Route
645
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
645