通过500ppm和200ppm的低酸和5.25%的低酸盐溶解人类纸组织的比较评估:一种
Siddheswaran Vijayaraghavan1, Krutika Menon2
1Department of Conservative Dentistry & Endodontics, College of Dental Sciences, Davanagere, Karnataka, India.
The journal of contemporary dental practice
|June 5, 2023
概括
低酸 (NaOCl) 仍然是最有效的在体外溶解人体纤维组织的药物. 酸显示出潜力,有效性随着度和时间的增加而增加,这表明未来对根管治疗的研究.
科学领域:
- 生物化学 生化学
- 生物材料科学 生物材料科学
- 牙科研究 牙科研究
背景情况:
- 低酸 (NaOCl) 是一种广泛用于牙周内科的灌剂.
- 它在溶解有机组织方面的有效性已被证实.
- 对其潜在的细胞毒性和实质性存在担忧.
研究的目的:
- 为了比较500ppm和200ppm的低酸 (HOCl) 的体外人体纸溶解能力与5.25%的NaOCl.
- 评估时间对这些药物的溶解效率的影响.
主要方法:
- 标准化的人类纸组织样本 (9毫克) 被暴露在5.25%的NaOCl,500ppm的HOCl,200ppm的HOCl或蒸水中.
- 样品被化了30或60分钟.
- 通过测量过和干燥后的残余重量来量化组织溶解.
主要成果:
- 5.25%NaOCl在两个时间点都表现出最高的纸溶解效率.
- 500 ppm的HOCl显示出明显的溶解,特别是在60分钟后.
- 200 ppm的HOCl显示出最小的溶解,特别是在30分钟后,而蒸水没有任何影响.
结论:
- 5.25%NaOCl是最有效的药物在人体皮质组织溶解在体外.
- HOCl 具有剂量依赖和时间依赖的纤维溶解能力.
- 对优化HOCl度和输送的进一步研究可能会导致其在根管治疗中作为NaOCl的更安全替代品.
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