相关实验视频
Updated: Jul 28, 2025

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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
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[儿童因温克里斯诱导的外周神经病变的队列研究]
Chuang Li1, Jiao Jin1, Jing Huang1
1Department of Pediatrics, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China.
概括
温克里斯诱导的周围神经病变 (VIPN) 影响近一半患有急性淋巴细胞白血病 (ALL) 的儿童. 10岁以上的儿童患VIPN的风险更高,自主神经系统症状最常见.
科学领域:
- 儿科瘤学 儿科瘤学
- 神经瘤学神经瘤学
- 临床药理学 临床药理学
背景情况:
- 文克里斯是儿童急性淋巴细胞白血病 (ALL) 的关键化疗剂.
- 温克里斯诱导的周围神经病变 (VIPN) 是一种常见的剂量限制性毒性.
- 了解儿科ALL的VIPN特征对于优化治疗和支持性护理至关重要.
研究的目的:
- 调查ALL儿童中VIPN的发生率,严重程度和类型.
- 确定影响该人口中VIPN发展的因素,特别是年龄.
- 分析VIPN的临床表现,包括自主和外围神经的参与.
主要方法:
- 分析了一组120名 (1-18岁) 用CCCG-ALL疗法治疗的儿童队列.
- 使用国家癌症研究所常见术语标准对不良事件 (CTCAE v5.0) 进行评估和分级VIPN.
- 儿童被分为多层次的年龄组 (1-10岁和>10岁) 来比较VIPN的发病率和特征.
主要成果:
- 总体VIPN发生率为46.7% (120名儿童中56名).
- 10岁以上的儿童的VIPN发病率 (69%) 与较小的儿童 (40%) 相比显著更高.
- 自主神经系统症状是最常见的表现 (59.7%),其次是外围神经损伤 (32.5%). 年龄被确定为一个重要的影响因素 (P<0.05).
结论:
- VIPN经常发生在儿科ALL患者中,显着倾向于自主神经系统参与.
- 年龄较大的儿童 (>10岁) 面临患VIPN的风险更高.
- 年龄是影响ALL治疗儿童出现VIPN的关键因素.
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