预测净管理活动在
Eric C Henry1, Benjamin Lopez1, Armeen Mahvash2
1Department of Imaging Physics, UT MD Anderson Cancer Center, Houston, Texas, USA.
Medical physics
|June 5, 2023
概括
在90Y放射性栓塞中,精确测量净施用活性 (阿胺) 是至关重要的. 新型SPECT/CT成像可靠地预测玻璃和树脂微球的Aadmin,改善剂量测量和安全性.
科学领域:
- 核医学就是核医学.
- 辐射物理学 辐射物理学
- 医疗成像医学成像
背景情况:
- 准确的净被施用活性 (Aadmin) 的确定对于90Y放射栓塞的剂量测量和辐射安全至关重要.
- 目前用于测量残留90Y活性的方法往往具有很高的不确定性.
- 需要一种临床上可行的方法来在不同的90Y微球器件中确定Aadmin.
研究的目的:
- 开发和验证一种使用定量SPECT/CT成像来确定Aadmin的新方法.
- 用玻璃或树脂微球测量90Y放射栓塞后的体内90Y排放.
主要方法:
- 对147名接受90Y放射栓塞的患者的减弱校正90Y-SPECT/CT数据的分析.
- 开发单变线性回归模型以基于SPECT计数预测Aadmin,分层按微球类型 (玻璃/树脂) 和SPECT体积 (FOV/VOIliver) 分层.
- 使用培训和测试队伍对模型性能进行独立评估,并进行一次性交叉验证.
主要成果:
- 对于微球类型和分析体积,90Y-SPECT计数和Aadmin之间的强正相关性 (R2>0.98).
- 高精度 (>96.9%) 和精度 (<26.2%) 在预测玻璃和树脂微球的测试队列中的 Aadmin 中.
- 在玻璃和树脂微球装置之间观察到活动校准的显著差异,树脂在每等效活动中产生更高的SPECT计数.
结论:
- 90Y-SPECT/CT成像提供了一种可靠的方法来预测90Y放射栓塞后的阿德明,准确度>95%和精度<18%.
- 该方法证明玻璃和树脂微球的性能相同.
- 在玻璃和树脂90Y微球器件之间,活动校准过程显著不同.
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