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表达矢量位置对转基因转录的影响,允许在有针对性的集成系统中进行理性表达矢量设计

Kathryn M Beal1, Kalpanie R Bandara1, Syed R Ali1

  • 1Cell Line Development, Bioprocess R&D, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts, USA.

Biotechnology journal
|June 5, 2023
PubMed
概括

特定站点整合 (SSI) 系统改善了重组中国大鼠卵巢 (CHO) 细胞系的发展. 新的方法优化转基因表达和单克隆和多特异性抗体的产品质量.

关键词:
在CHO细胞中.细胞生物学 细胞生物学表达系统表达系统.基因表达的基因表达方式分子生物技术分子生物技术

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