在大B细胞淋巴瘤中使用Axicabtagene Ciloleucel的生存率
Jason R Westin1, Olalekan O Oluwole1, Marie José Kersten1
1From University of Texas M.D. Anderson Cancer Center, Houston (J.R.W.); Vanderbilt-Ingram Cancer Center, Nashville (O.O.O.); Amsterdam University Medical Center (UMC), University of Amsterdam, Cancer Center Amsterdam, Amsterdam (M.J.K.), UMC Groningen, Groningen (T.M.), and UMC Utrecht, Utrecht (M.C.M.) - all in the Netherlands; Stanford University School of Medicine, Stanford (D.B.M.), and Kite, Santa Monica (Y.Y., S.V., S.F., P.C., S.A.S., M.S., C.T.) - both in California; Memorial Sloan Kettering Cancer Center, New York (M.-A.P.), and University of Rochester School of Medicine, Rochester (P.M.R.) - both in New York; Washington University School of Medicine, St. Louis (A.G.); Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore (A.P.R.); Servei d'Hematologia Clínica, Institut Català d'Oncologia-Hospitalet, Institut de Recerca Biomèdica de Bellvitge, Universitat de Barcelona, Barcelona (A.S.B.); Dana-Farber Cancer Institute, Boston (C.A.J.); University of Iowa, Iowa City (U.F.); Banner M.D. Anderson Cancer Center, Gilbert, AZ (M.U.); the Division of Hematology and Hematologic Oncology, Department of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, NS (M.E.), and Vancouver General Hospital, BC Cancer, University of British Columbia, Vancouver (K.W.S.) - both in Canada; John Theurer Cancer Center, Hackensack, NJ (L.A.L.); the Centre for Clinical Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom (S.C.); Peter MacCallum Cancer Centre, Royal Melbourne Hospital, and the University of Melbourne, Melbourne (M.D.); UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh (K.D.); University of Kansas Cancer Center, Kansas City (J.M.); David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago (P.A.R.); and Moffitt Cancer Center, Tampa, FL (F.L.L.).
与标准治疗相比,axicabtagene ciloleucel (axi-cel) 显著改善了早期复发或耐药的大B细胞淋巴瘤患者的整体存活率. 这种CAR T细胞疗法为这些患者提供了有前途的长期益处.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- 大型B细胞淋巴瘤 (LBCL) 是一种具有攻击性的血液性恶性瘤.
- 早期复发性或耐药性LBCL是一个重大的治疗挑战.
- 自主抗CD19仿真抗原受体T细胞疗法 (axi-cel) 是一种新的治疗方式.
研究的目的:
- 评估axicabtagene ciloleucel (axi-cel) 作为LBCL的二线治疗的长期疗效和安全性.
- 在早期复发或耐药LBCL的患者中,比较轴细胞和标准护理之间的整体存活率 (OS).
- 报告ZUMA-7试验的5年结果.
主要方法:
- 第三阶段,随机对照试验比较轴细胞与标准治疗在359名早期复发/耐药LBCL的患者.
- 标准治疗包括化疗免疫疗法,然后是高剂量化疗和对响应者进行自身干细胞移植.
- 主要终点是无事件生存;次要终点包括反应和整体生存.
主要成果:
- 随访时间中位数为47.2个月,与标准护理相比,与轴细胞相比,与标准护理相比,与31.1个月相比,与轴细胞相比,与标准护理相比,与轴细胞相比,没有达到中位数.
- 在4年后的生存率为54.6%,与轴细胞治疗相比,在标准治疗中为46.0% (HR 0.73;P=0.03).
- 与轴细胞 (14.7个月与3.7个月) 相比,无进展生存时间的中位数显着更长.
结论:
- 与标准护理相比,axicabtagene ciloleucel (axi-cel) 显示的整体存活时间明显更长,作为LBCL的二线治疗.
- 在早期复发或耐药LBCL的患者中,Axi-cel提供了持久的长期益处.
- 这些发现支持axi-cel作为这种患者群体的标准护理.
更多相关视频
12:16A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
Published on: October 16, 2018
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
相关概念视频
Treatment Resistant Cancers
Tumor Immunotherapy
Targeted Cancer Therapies
There are several types of targeted therapies against...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)