在被切除的EGFR突变NSCLC患者中,Osimertinib的整体存活率EGFR
Masahiro Tsuboi1, Roy S Herbst1, Thomas John1
1From the Department of Thoracic Surgery and Oncology, National Cancer Center Hospital East, Kashiwa (M.T.), the Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama (T.K.) - both in Japan; the Section of Medical Oncology, Yale School of Medicine and Yale Cancer Center, New Haven, CT (R.S.H.); the Department of Medical Oncology, Peter MacCallum Cancer Centre, and the Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia (T.J.); the Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona (M.M.); Klinik für Pneumologie, Evangelische Lungenklinik Berlin Buch, Berlin (C.G.); Cancer Hospital, Chinese Academy of Medical Sciences, Beijing (J.W.), Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai (S.L.), and Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou (Y.-L.W.) - all in China; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (J.W.G.); the Department of Oncology, National Cheng Kung University, Tainan, Taiwan (W.-C.S.); the Division of Thoracic Oncology, European Institute of Oncology, IRCCS, Milan (F.M.); the Department of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre (F.A.S.), and Oncology Research and Development, AstraZeneca (A.B.) - both in Toronto; the Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, South Korea (K.H.L.); Ho Chi Minh City Oncology Hospital, Binh Thanh District, Ho Chi Minh City, Vietnam (N.T.L.); the Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand (A.D.); the Department of Lung Cancer and Thoracic Tumors, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland (D.K.); and Oncology Biometrics (L.P.), and Oncology Research and Development (Y.R.), AstraZeneca, Cambridge, United Kingdom.
辅助性奥西默提尼布显著改善了切除EGFR突变NSCLC的患者的整体存活率. 对ADAURA试验的最终分析证实了对早期肺癌的长期益处.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 临床试验 临床试验
背景情况:
- 在ADAURA试验中,研究了辅助性奥西默蒂尼布在切除,EGFR突变的IB-IIIA阶段非小细胞肺癌 (NSCLC) 中.
- 之前的研究结果显示,与安慰剂相比,用 osimertinib 改善了无病生存率.
- 本报告介绍了最终的整体存活率 (OS) 分析.
研究的目的:
- 确定辅助性奥西默蒂尼布对切除EGFR突变NSCLC的患者整体存活期的影响.
- 报告ADAURA试验的最终生存结果.
主要方法:
- 第三阶段,双盲,随机对照试验,比较奥西默蒂尼布与安慰剂.
- 患者每天接受80毫克奥西默提尼布或安慰剂,直到疾病复发,完成3年或停止治疗.
- 主要终点是II-IIIA阶段的无病生存 (DFS);次要终点包括OS和安全.
主要成果:
- 在II-IIIA阶段的NSCLC中,5年生存率为85%与osimertinib相比,与安慰剂相比为73% (HR0.49,P<0.001).
- 在整体人群中 (IB-IIIA阶段),五年生存率为88%与 osimertinib 相比78%与安慰剂 (HR 0.49,P<0.001).
- 副作用与之前的分析一致;没有报告与试验方案相关的新安全问题.
结论:
- 辅助性奥西默提尼布显著改善了切除,EGFR突变,IB-IIIA期NSCLC的患者的整体存活率.
- 这些发现证实了这种患者群体的长期生存益处.
更多相关视频
07:59Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
09:38Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
Published on: August 11, 2017
相关概念视频
Cancer Survival Analysis
Treatment Resistant Cancers
