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基于Azines的Schiff基及其Pd (II) 复合物的合成,表征,抗菌和抗疟活性

Kiran Meena¹, Prabhat Kumar Baroliya¹

¹Department of Chemistry, Mohanlal Sukhadia University, Udaipur, 313001, India.

Chemistry & biodiversity

|June 5, 2023

概括

新的azine Schiff基联体及其复合物显示出有前途的抗微生物和抗疟疾活性. 连接物L4和复合物C4对分别S. aureus和P. falciparum表现出显著的活性.

科学领域:

协调化学协调化学
药用化学医学化学
抗菌剂抗菌剂抗菌剂
抗疟疾药物抗疟疾药物

背景情况:

希夫基是协调化学中的多功能连接体.
帕拉复合体是为了它们的生物活动而被探索的.
阿齐内·希夫的基座为金属复合提供了独特的结构图案.

研究的目的:

合成和表征新型阿酸希夫基联体及其 (II) 复合体.
评估合成的化合物是否具有抗微生物和抗疟疾的特性.
为了建立这些复合物的结构-活性关系.

主要方法:

通过凝结反应合成阿酸希夫基联体 (L1-L4).
使用乙酸盐制备 (C1-C4) 复合物 (C1-C4).
使用光谱技术进行表征 (NMR,FT-IR,质谱学).
对抗细菌 (S. aureus,B. subtilis,S. typhi,P. aeruginosa) 和真菌 (C. albicans,A. niger,A. clavatus) 的抗菌活性进行查.
评估抗疟疾活性对抗黄菌.

主要成果:

成功合成和表征了四种亚基希夫基联体及其相应的 (II) 复合物.
连接物L4表现出强烈的抗菌活性对黄金色杆菌 (MIC,50μg/mL).
复合体C1对S. typhi (MIC,62.5μg/mL) 显示出显著的抗菌活性.
复合体C4对P. falciparum (IC50,0.42μg/mL) 显示出显著的抗疟疾活性.

结论:

阿希夫基联体及其 (II) 复合物具有显著的抗微生物和抗疟疾潜力.
合成的化合物,特别是L4和C4,是作为治疗剂进一步开发的有希望的候选物.
对这些复合物的进一步探索可能会导致新型抗微生物和抗疟疾药物的发现.

关键词:

这里是船只基地.它具有抗菌活性,具有抗菌活性.抗真菌活动的抗真菌活性.它具有抗疟疾活性.帕拉复合体是一个复合体.

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