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ангиотензин转化酶2激活不是 ангиотензин转化酶抑制的常见特征
Zihan Wang1,2, Hongbing Fan1,2, Xiaoyu Bao1
1Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-10 Ag/For Building, Edmonton, Alberta T6G 2P5, Canada.
Journal of agricultural and food chemistry
|June 5, 2023
概括
某些血管素转化酶 (ACE) 抑制性可以激活ACE2,促进血管扩张. 然而,ACE2激活并不是所有ACE抑制的普遍作用,正如高血压大鼠模型所示.
科学领域:
- 心血管药理学心血管药理学
- 生物化学 生物化学
- 分子生物学分子生物学
背景情况:
- 氨酸 - 血管素系统 (RAS) 调节血压.
- ангиотензин转化酶 (ACE) 产生血管缩剂 ангиотензин II (Ang II). 血管缩剂 ангиотензин II (Ang II). 血管缩剂 ангиотензин II (Ang II). 血管缩剂 ангиотензин II (Ang II). 血管缩剂 ангиотензин II (Ang II). 血管缩剂 ангиотензин
- 在ACE2的代谢过程中,Ang II被转化为血管扩张剂 ангиотензин (1-7) [Ang (1-7) ].
研究的目的:
- 调查是否ACE抑制性 (ACEi) 也可以激活ACE2.
- 探索ACEi在调节ACE/ACE2平衡中的潜力.
主要方法:
- 使用分子对接对约200个ACEi的选.
- 对20种选定的的体外酶活性和基于细胞的测定.
- 在7天内,口服给自发高血压大鼠 (SHR) 5种.
主要成果:
- 基IKW和RIY表现出显著的抗高血压作用,激活循环和大动脉ACE2,增加Ang (1-7),并降低Ang II.
- IQY降低了血压,增加了Ang (1-7),但没有改变ACE或ACE2活性.
- 酸MAW和MRW对血压,ACE或ACE2没有显著影响.
结论:
- 激活ACE2并不是所有ACE抑制共享的共同特征.
- 特定的ACEi,如IKW和RIY,通过有利地调节ACE/ACE2轴,具有心血管治疗的潜力.
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