复杂的化学信号通过肠肺轴决定Ah受体的激活
Fangcong Dong1, Iain A Murray1, Andrew Annalora2
1Department of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, USA.
饮食中的化合物,如乌罗氨酸A (UroA),可以通过作为CYP1A1/1B1基质来增强氨酸碳化合物受体 (AHR) 的激活. 这改善了AHR连接体向组织的分发,促进了屏障平衡.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 基碳化合物受体 (AHR) 对于肠壁平衡至关重要.
- 许多AHR配体被肠道中的CYP1A1/1B1酶迅速清除,限制了它们的全身作用.
- 这就需要策略来延长AHR连接体半衰期并增强AHR激活.
研究的目的:
- 为了研究是否urolithin A (UroA),一个基坦宁的代谢物,可以作为CYP1A1/1B1基质来增强AHR活性.
- 为了确定饮食中的CYP1A1/1B1基质是否可以改善AHR配体的系统分布和疗效.
主要方法:
- 在体外竞争测试以评估UroA对CYP1A1/1B1.1的基质潜力.
- 在小鼠食含有西兰花的饮食中,食UroA促进了AHR配体5,11-dihydroindolo[3,2-b]carbazole (ICZ) 的形成.
- 测量各种组织 (十二指肠,肝脏,心脏,肺部) 的AHR活性,以评估系统分布和激活.
主要成果:
- 乌罗立A在体外具有竞争性抑制CYP1A1/1B1的作用.
- 食UroA,与西兰花饮食相结合,增加了十二指肠,心脏和肺部的AHR活动,但不是肝脏.
- 这表明从肠道中增强了AHR配体的系统分布.
结论:
- 食CYP1A1/1B1基质,如UroA,可以延长AHR配体的半衰期.
- 这种机制增强了全身AHR连接体的分布,可能是通过淋巴系统.
- 在肠道,心脏和肺部等屏障组织中增加了AHR激活,这对了解疏水性化学物质分布有意义.
更多相关视频
07:29Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
Published on: December 29, 2023
09:31Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model
Published on: November 9, 2018
相关概念视频
Endocrine Signaling
Sympathetic Signaling
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Regulation of the Digestive System
The effectors in this regulation system are glands and smooth muscles. Activation of...
Chemical Signaling in the Endocrine System
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
Secondary Messengers in Hormone Action
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
Cell Signaling in Plants
