基于架构的编程,使聚合物微粒经历连续的中相过渡
Parul Rathee1,2,3, Nicole Edelstein-Pardo1,2,3, Francesca Netti2,3,4
1School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel.
ACS macro letters
|June 5, 2023
概括
具有不同架构的两类块共聚合物可以被编程为米塞尔,水凝和溶解状态之间的顺序过渡. 这种受控的降解允许智能配方设计和货物交付.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 超分子化学 超分子化学
背景情况:
- 两和三两细胞自组成各种中相,如和水凝.
- 它们的分子架构影响自我组装,汇率和对降解的反应性.
- 现有的配方缺乏对连续相位过渡的精确控制.
研究的目的:
- 为了利用二阻和三阻两的差异性酶降解速率,用于编程的中相过渡.
- 为了证明从米塞尔到水凝到溶解聚合物的连续过渡.
- 为了证明配方比率可以控制过渡率和货物保留.
主要方法:
- 合成了具有相同水友性-脂友性平衡的二-和三块两活体.
- 研究了不同两结构的酶降解动力学.
- 配制了二-和三阻塞两动物的混合物,以诱导连续的中相变化.
- 在水凝阶段内评估货物保留.
主要成果:
- 双阻塞和三阻塞两活体对酶降解具有明显的反应性.
- 配方经历了编程的过渡:米塞尔 -> 水凝 -> 溶解的聚合物.
- 过渡速率可以通过调整混合物中的两比率来调整.
- 形成的水凝在过渡过程中保持封装的货物.
结论:
- 分子架构是编程智能两制剂的一个关键因素.
- 可以实现序列的,由酶诱导的中相过渡.
- 这种方法可以控制材料的行为和在药物输送和响应材料中的潜在应用.
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