在人类的久坐式生活方式中,运动和血管功能
Babatunde Fasipe1, Shunchang Li2, Ismail Laher3
1Faculty of Basic Clinical Sciences, Department of Pharmacology and Therapeutics, Bowen University, Iwo, Nigeria.
Pflugers Archiv : European journal of physiology
|June 5, 2023
概括
久坐不动的生活方式增加了氧化应激和血管损伤. 定期或高强度运动会激活保护性通路,而高强度运动对久坐的人来说可能会带来更大的好处.
科学领域:
- 生理学 生理学 生理学
- 细胞生物学 细胞生物学
- 血管健康 血管健康
背景情况:
- 久坐不动的生活方式会破坏细胞的氧化还原平衡和线粒体功能.
- 这导致氧化应激增加,内皮功能障碍和血管炎症.
- 关键的分子变化包括NADPH氧化酶活性增加和氧化 (NO) 生物可用性降低.
研究的目的:
- 审查久坐不动的生活方式对血管的有害影响.
- 探索定期和间歇性运动对血管健康的益处.
- 为了比较不同强度的运动对NRF2激活的有效性.
主要方法:
- 关于久坐行为,氧化应激和运动生理学的科学文献的综述.
- 分析连接生活方式,细胞压力和血管功能的分子机制.
- 检查信号通路,如NRF2-KEAP,并通过运动调节它们.
主要成果:
- 久坐不动的行为促进氧化应激,通过LDL-C氧化和降低NO的内皮功能障碍,以及eNOS脱.
- 运动,特别是通过活性氧物种 (ROS),激活NRF2通路,以对抗氧化应激.
- 高强度间歇性运动通过降低KEAP水平与中度运动相比,显示出更大的NRF2激活潜力.
结论:
- 久坐不动的生活方式通过氧化压力对血管健康构成重大风险.
- 通过激活保护性细胞通路,定期炼对于减轻这些风险至关重要.
- 高强度间歇性运动可能为久坐不动的人提供优越的益处,减轻氧化应激和改善血管功能.
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