对于PM的影响
Hao Cui1,2,3, Ye Qi1,3,4,5,6, Chunyue Guo1,3
1The Third Central Clinical College of Tianjin Medical University, 83 Jintang Road, Hedong District, Tianjin, 300170, China.
概括
暴露于细颗粒物 (PM2.5) 显著增加了中国肝细胞癌 (HCC) 患者的死亡风险. 较高的PM2.5水平与更大的生存影响相关,特别是在老年人和城市居民中.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 颗粒物 (PM2.5) 与呼吸道和心血管问题有关.
- 有限的队列证据证明PM2.5对中国肝细胞癌 (HCC) 存活率的影响.
- 了解环境风险因素对于HCC患者的治疗结果至关重要.
研究的目的:
- 评估PM2.5暴露与中国HCC患者死亡率之间的关联.
- 量化与不同PM2.5度相关的死亡风险.
主要方法:
- 从2013年9月到2018年12月,对1440名HCC患者进行的队列研究.
- 使用逆距离加权 (IDW) 方法评估的PM2.5暴露.
- 生存分析采用了卡普兰-梅尔,限制立方线和考克斯比例危险模型.
主要成果:
- 暴露于PM2.5≥58.56μg/m3的HCK患者的死亡率显著更高 (79.0%与50.7%相比).
- 观察到PM2.5度与死亡风险之间存在线性关系.
- 每增加10μg/m3的PM2.5都会使HCC的死亡风险增加44% (HR = 1.44,P < 0.001).
结论:
- 在HCC诊断后增加的PM2.5暴露会对患者的存活率产生负面影响.
- 死亡风险随着PM2.5度的增加而增加.
- PM2.5对HCC死亡率的影响在60岁以上的患者和城市地区的患者中更为明显.
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