在ABCD研究中,多基因对个人违反规则,同行违反规则和酒精透到青春期早期的影响
Kit K Elam1, Jinni Su2, Fazil Aliev3
1Department of Applied Health Science, Indiana University, 1025 E. 7th St., Suite 116, Bloomington, IN, 47405, USA. kitelam@iu.edu.
Research on child and adolescent psychopathology
|June 5, 2023
概括
风险行为的遗传倾向影响青少年的酒精使用,特别是通过违规行为. 基因环境相关性 (rGE) 在欧洲裔美国人中发挥作用,将违规与早期的酒精饮用联系起来.
科学领域:
- 青少年心理学 青少年心理学
- 行为遗传学行为遗传学
- 药物使用研究研究.
背景情况:
- 青少年早期的酒精使用与危险,犯罪和违规行为有关.
- 风险承担的遗传倾向可以影响个人和同行违反规则,可能通过基因环境相关性 (rGE) 增加酒精使用风险.
- 有限的研究存在于不同的青少年群体中对酒精使用规则破坏途径的遗传贡献.
研究的目的:
- 研究遗传倾向对个人和同行违反规则和饮酒风险行为的作用.
- 检查这些关系在早期青春期的发展途径.
- 分析这些跨不同种族/种族小组 (欧洲裔美国人,非洲裔美国人,西班牙裔/拉丁裔) 的关联.
主要方法:
- 利用了青少年大脑认知发展 (ABCD) 研究的数据.
- 采用交叉时间,交叉滞后模型,检查多基因分数的风险行为.
- 分析了11-12岁和12-13岁的欧洲裔美国人 (n=5113),非洲裔美国人 (n=1159) 和西班牙裔/拉丁裔 (n=1624) 小组的数据,控制了共变量和遗传血统.
主要成果:
- 风险行为的多基因分数与欧洲裔美国人的违规行为和酒精饮用有关.
- 在非洲裔美国人和西班牙裔/拉丁裔青年中发现了与个人违反规则的关联,在11-12岁的西班牙裔/拉丁裔青年中发现了饮酒.
- 12-13岁的同龄人违反规则预测了所有子组的酒精饮料,在欧洲裔美国人中观察到个人和同龄人违反规则之间的联系更强烈.
结论:
- 青少年早期的酒精饮酒与个人和同行违规行为有关.
- 基因环境相关性 (rGE) 似乎与从遗传倾向到酒精使用的途径有关,特别是在欧洲裔美国青少年中.
- 研究结果强调了青少年开始饮酒时遗传和环境因素的复杂相互作用.
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