在德国,Tecovirimat用于治疗严重的Mpox
Lennart Hermanussen1, Thomas Theo Brehm1,2, Timo Wolf3
1Division of Infectious Diseases, I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Infection
|June 5, 2023
概括
在德国,对严重的mopox进行tecovirimat治疗,在12名患者中显示出良好的耐受性和临床改善. 这项研究突出了tecovirimat的重点.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 一个多国波克斯疫情于2022年5月开始,影响了非流行国家.
- 德科维里马特是唯一获得欧盟许可的口服治疗mopox,向Orthopox病毒包膜蛋白.
研究的目的:
- 为了评估德意志mpox患者tecovirimat的疗效和耐受性.
- 为了评估严重的mopox病例队列中的治疗结果.
主要方法:
- 在德国接受tecovirimat治疗的十二名mopox患者的回顾性分析 (2022年5月 - 2023年3月).
- 数据收集包括通过标准化病例报告表格收集人口统计和临床特征.
主要成果:
- 十二名mpox患者接受了tecovirimat;大多数是与男性发生性关系的男性 (MSM),有几名艾滋病毒感染者 (PLWH).
- 治疗指示包括严重的免疫抑制,持续的症状,多种病变或关键病变位置.
- 所有患者在6-28天的特科维里马特治疗后都出现了临床缓解,这种疗法通常耐受良好.
结论:
- 德科维里马特表现出良好的耐受性,并导致严重的mopox病例的临床改善.
- 这些发现支持tecovirimat在治疗严重的mopox感染中的作用.
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