大脑结构是自闭症谱系障碍儿童的同情-系统化差异的基础
Ning Pan1, Li-Zi Lin2, Xin Wang3,4
1Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan Road 2, Yuexiu District, Guangzhou, 510080, China.
World journal of pediatrics : WJP
|June 5, 2023
概括
患有自闭症谱系障碍 (ASD) 的儿童显示出他们的同情-系统化差异 (D分数) 和大脑结构之间的联系. 杏仁体体积和左侧尾皮层 (LOC) 转移可能作为这种ASD差异的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 自闭症谱系障碍研究研究
背景情况:
- 行为研究表明,与典型发育儿童相比,自闭症谱系障碍 (ASD) 儿童的同情-系统化差异 (D分数) 较大.
- 现有的研究缺乏对ASD儿童这种同情-系统化差异的神经解剖学基础的调查.
研究的目的:
- 探索与ASD儿童同情-系统化差异相关的神经解剖机制.
- 研究ASD儿童和典型发育 (TD) 儿童的大脑形态测量和D分数之间的关系.
主要方法:
- 结构磁共振成像 (MRI) 用于量化41名患有自闭症儿童和39名TD儿童 (6至12岁) 的大脑形态测量.
- 测量包括全球和区域大脑体积和基于表面的皮质特征 (皮质厚度,表面积,旋转).
- 对同情与系统化的差异进行了评估,使用D分数从中国版本的儿童同情率和系统化率中获得的D分数.
主要成果:
- 在患有自闭症的儿童中,D分数和杏仁体灰质体积之间发现了显著的负相关性.
- 在患有自闭症的儿童中,D分数和左侧尾皮层 (LOC) 变之间存在负相关性.
- 在TD儿童中观察到D分数和右状缩之间存在积极的关联,在两组之间观察到杏仁体体积和左LOC缩之间存在显著的相互作用.
结论:
- 杏仁体体积和LOC转化的神经解剖学变异可能代表ASD儿童同情-系统化差异的潜在生物标志物.
- 这些大脑结构在典型发育的儿童中没有显示类似的关联.
- 这些发现的可复制性需要大规模的神经成像研究.
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