对结直肠癌患者预后模式的回顾性研究
Jayaditya Devpal Patil1, Yusuf Mahdi Mohamed2, Raed AlMarzooq3
1Obstetrics and Gynaecology, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Cureus
|June 5, 2023
概括
巴林的结肠直肠癌 (CRC) 患者表现出有利的解剖学和组织病理学因素,但涉及分子预后. 需要进一步的研究来改进CRC管理策略.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 医学研究 医学研究
背景情况:
- 结肠直肠癌 (CRC) 管理在全球范围内得到改善,但预后因瘤部位,等级和突变而异.
- 越来越多的CRC发病率需要更新的描述性研究,以获得更好的患者结果.
- 在CRC患者的预后因素需要持续调查,以改进治疗策略.
研究的目的:
- 研究结直肠癌 (CRC) 患者的解剖学,组织病理学和分子预后因素.
- 为巴林萨尔曼尼亚医疗综合体 (SMC) 的CRC病例提供最近的描述性分析.
- 确定影响CRC预后的关键因素,以改善临床管理.
主要方法:
- 从2019年1月到2020年12月,利用ISEHA电子数据库进行了回顾性研究.
- 包括来自一般外科的101名原发性结肠直肠癌 (CRC) 患者.
- 对解剖学,遗传病理学和分子数据进行描述性统计分析.
主要成果:
- 左侧结肠瘤是最常见的 (65%),其中16.8%是直肠瘤.
- 大多数患者 (86%) 患有低度腺癌;最常见的阶段是pT3N0M0.
- TP53 (27.7%) 和KRAS (29%) 基因突变是最常见的,发现了10例转移性病例.
结论:
- 巴林SMC的CRC患者通常表现出有利的解剖学和组织病理预后因素.
- 分子预后,特别是基因突变,在这个队列中呈现CRC更具挑战性的方面.
- 调查结果强调了需要量身定制的管理策略,考虑到结直肠癌的各种预后指标.
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