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A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
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耐受性树突细胞报告:一个最小信息模型是否有所作为?

Ayesha Sahar1, Ioana Nicorescu2, Gabrielle Barran2

  • 1School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom.

PeerJ
|June 5, 2023
PubMed
概括
此摘要是机器生成的。

关于耐受性抗原呈现细胞 (MITAP) 报告框架的最小信息在耐受性树突细胞 (tolDCs) 领域的采用率有限 (14%). 虽然它稍微改善了元数据,但在细胞治疗研究中需要更广泛的标准化报告.

关键词:
细胞疗法是一种细胞疗法.公平的数据是公平的.分享元数据的共享.最少信息模型的模型.开放的数据共享.报告准则 报告准则报告标准化的数据报告.宽容性树突细胞的宽容性.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞疗法细胞疗法
  • 生物技术是生物技术.

背景情况:

  • 最低信息模型标准化科学报告,以实现可重复性和比较性.
  • 包容性抗原呈现细胞 (tolAPCs),包括包容性树突细胞 (tolDCs),对于免疫耐受性和细胞疗法至关重要.
  • 现有的生成tolDC的协议具有很大的变化,需要标准化报告.

研究的目的:

  • 评估对宽容性抗原呈现细胞 (MITAP) 框架的最小信息的影响和采用.
  • 评估MITAP在tolDC研究领域影响了报告标准的程度.

主要方法:

  • 关于tolDCs的一部分出版物的文献综述.
  • 在选定的文献中分析MITAP框架的使用情况.
  • 在使用MITAP的论文中量化元数据的可用性,与不使用MITAP的论文相比.

主要成果:

  • 在经过检查的tolDC文献中,MITAP仅在14%使用.
  • 与非MITAP论文相比,使用MITAP论文的可用元数据略有增加.
  • 通过MITAP采用标准化的报告是有限的.

结论:

  • 在tolDC领域,MITAP已经取得了部分成功.
  • 需要做出重大努力来增加MITAP的采用率,并实现广泛的标准化报告.
  • 为了使MITAP对细胞治疗研究产生更广泛的影响,需要进一步的社区参与和整合.