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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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老化的大脑显示了大脑在网络内和网络之间的连接性联合下降:一个大样本研究 (

Yuhui Du1,2, Yating Guo1, Vince D Calhoun2

  • 1School of Computer and Information Technology, Shanxi University, Taiyuan, China.

Frontiers in aging neuroscience
|June 5, 2023
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概括

这项研究揭示了各种全脑衰老效应,显示了大脑网络内部和大脑网络之间功能网络连接的改变. 这些发现突出了协同作用和矛盾的变化,为非病理性大脑衰老提供了新的见解.

关键词:
这就是NeuroMark.大脑功能网络大脑功能网络功能网络连接性的功能网络连接.联合变化 联合变化这是正常的大脑衰老.

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科学领域:

  • 神经成像是一种神经成像.
  • 大脑衰老 老龄化
  • 功能连接的功能连接性

背景情况:

  • 衰老会影响特定的大脑网络,并减少功能连接.
  • 之前的研究还没有全面研究整个大脑衰老对网络内部和网络之间的连接的影响.
  • 了解这些变化对于描述非病理性大脑衰老至关重要.

研究的目的:

  • 研究衰老对全脑功能网络 (FNs) 和功能网络连接 (FNC) 的影响.
  • 识别网络内部和网络之间的连接中与老化相关的变化.
  • 探索FN和FNC之间的协同作用和矛盾变化.

主要方法:

  • 利用了一大批英国生物库数据集 (6,300名健康成年人,49-73岁).
  • 使用先验驱动的独立组件分析 (ICA) 通过NeuroMark提取FN和FNC.
  • 应用了双层统计分析和综合方法来分析衰老影响和关节变化.

主要成果:

  • 老化改变了网络内部和网络之间的连接.
  • 观察到FNCs在域内和域之间减少 (视觉,认知控制,小脑).
  • 增强的FNC主要发生在域 (默认模式,认知控制) 之间;在传感动力网络中,网络内部连接性增加,而连接性减少涉及默认模式网络.

结论:

  • 衰老在整个大脑的功能网络上表现出各种各样的影响.
  • 这项研究为非病理衰老过程中FN和FNC的复杂相互作用提供了新的见解.
  • 这些发现强调了大脑衰老过程的异质性.