放射性隔离综合征中高级中枢神经系统成像生物标志物:一个迷你回顾
Sara Collorone1, Michael A Foster1, Ahmed T Toosy1
1Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom.
Frontiers in neurology
|June 5, 2023
概括
放射性隔离综合征 (RIS) 显示了类似于多发性硬化症的大脑病变,但没有症状. 先进的成像技术有助于了解RIS的进展,并预测未来的结果.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 多发性硬化症研究研究
背景情况:
- 放射性隔离综合征 (RIS) 呈现中枢神经系统白质过强度,暗示MS.
- 患有RIS的个体没有临床脱髓化事件的病史.
- 据信RIS是MS的前症状阶段,但仍然不太了解.
研究的目的:
- 审查RIS中先进成像技术的当前知识.
- 探索这些技术如何为RIS病理生物学提供洞察力.
- 评估RIS中高级成像的预后价值.
主要方法:
- 综述使用先进磁共振成像 (MRI) 技术的研究.
- 分析MRI衍生标记,包括中枢神经系统体积和连接性.
- 包括中央静脉标志作为成像生物标志物.
- 考虑光学连贯性断层扫描 (OCT) 的指标.
主要成果:
- 先进的MRI技术揭示了RIS中中枢神经系统结构和功能的微妙变化.
- 中心静脉标志显示出作为诊断和预后指标的潜力.
- 海外国家和地区的指标可以提供有关RIS的轴突变化的见解.
结论:
- 先进的成像为RIS的潜在病理学提供了至关重要的见解.
- 这些技术有望预测RIS患者的疾病进展和临床转化.
- 需要进一步的研究,以充分阐明这些先进的成像模式在管理RIS中的作用.
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