长期影响的抗- 长期影响的抗-
Satoshi Hirose1, Makoto Hara1, Yuki Yokota1
1Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Frontiers in neurology
|June 5, 2023
概括
抗NMDA受体脑炎 (NMDARE) 患者经常经历长期的社会生活质量缺陷和持续的后果. 尽量减少急性阶段的后果可能会改善NMDARE幸存者的长期结果.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 抗N-甲基-d-酸盐受体脑炎 (NMDARE) 通常呈现出有利的神经恢复.
- 然而,持续的非运动性后果和降低生活质量 (QOL) 是NMDARE幸存者的常见长期挑战.
- 与NMDARE相关的护理人员负担很大,但长期患者的结果仍未得到充分研究.
研究的目的:
- 研究NMDARE对患者生活质量 (QOL) 的长期影响.
- 评估NMDARE幸存者的持续后果的患病率及其对日常功能和质量生活的影响.
主要方法:
- 对日本反NMDARE患者协会的成年成员进行了结构化,自我报告的问卷调查.
- 我们使用NeuroQOL电池来评估身体,精神和社会领域的QOL.
- 将NeuroQOL分数转换为T分数以与规范性对照数据进行比较.
主要成果:
- 22名NMDARE患者完成了这项研究,随访时间中位数为78个月.
- 46%的人报告持续的后果,只有73%的人恢复了以前的工作/学校活动.
- 虽然全球QOL与对照组相似,但NMDARE患者的社会QOL显著降低,这与更频繁的后果相关.
结论:
- 与一般人群相比,NMDARE幸存者经历了明显的社会质量生活损害.
- 持续的后果会对NMDARE患者的整体QOL产生负面影响.
- 专注于最大限度地减少急性期后果的早期治疗策略对于改善NMDARE的长期质量生活至关重要.
相关概念视频
Desensitization and Tachyphylaxis
1.9K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.9K
Effects of Chemicals: Overview
1.3K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.3K
Toxic Reactions: Overview
1.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.0K
Long-term Depression
31.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
31.1K
Local Anesthetics: Adverse Effects
459
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
459
Antiasthma Drugs: Leukotriene Modifiers
375
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
375


