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病例报告:由于与C677T多态相结合的高homocysteinemia导致的年轻发病的大血管缺血性中风

Jiro Fukae¹, Hiroto Eguchi¹, Yoichi Wada²

¹Department of Neurology, Juntendo University Nerima Hospital, Tokyo, Japan.

Frontiers in neurology

|June 5, 2023

概括

在一名患者中,由于MTHFR基因变异和维生素缺乏症,发现了高水平的同类半氨酸,这是中风的危险因素. 对服用抗发作药物的患者来说,定期监测同型半氨酸和叶酸是非常重要的.

科学领域:

神经学神经学
医学遗传学医学遗传学
生物化学生物化学

背景情况:

过高homocysteinemia是脑血管事件的一个公认的危险因素,包括缺血性中风.
患者,特别是那些服用多种抗药物的患者,容易发生代谢变化.
5.10-甲基联四叶酸还原酶 (MTHFR) C677T多态可能会影响同类氨酸代谢.

研究的目的:

报告一个由多因子高血糖蛋白质血症引起的年轻发作的中风病例.
为了突出MTHFR C677T多态,维生素缺乏和患者中风之间的联系.
强调在特定患者群体中监测同型半氨酸和叶酸水平的重要性.

主要方法:

一个30岁的男性患有,并出现中风症状的病例报告.
磁共振成像 (MRI) 用于识别缺血性脑损伤.
临床测试超同胞蛋白血症,MTHFR C677T多态性和维生素缺乏症.

主要成果:

由于左中脑动脉封闭,该患者经历了右半和全.
由于MTHFR C677T多形态和多种维生素缺乏症,被诊断出多因子高血糖蛋白质血症.
在这位患者中,确定了抗发作药物使用,MTHFR多态性和高同位素血之间的关联.

结论:

由于MTHFR C677T多态性和维生素缺乏而加剧的高血糖血,即使在年轻时也可能导致中风.
长期接受抗发作药物治疗的患者容易患上高血糖血症,需要定期监测.
定期测量血homocysteine和血清叶酸对于预防风险患者中风至关重要.

关键词:

10 - 甲基基酸盐减少酶.5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 6 6 6 6 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 8 8 8 8 8 8 8 8 8 8 8 8 8 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 including including including including including including 抗药物是一种抗药.大脑梗塞脑梗塞是一种.叶酸是一种叶酸.过高的同类细胞蛋白质血症维生素B12 维生素B12 是一种

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