病例报告:与SARS-CoV-2感染相关的皮肤肌炎异常患者
Joanna Niedzielska1, Monika Chaszczewska-Markowska2, Justyna Chojdak-Łukasiewicz3
1Department of Neurology, Specialist Medical Center in Polanica Zdrój, Polanica-Zdrój, Poland.
Frontiers in neurology
|June 5, 2023
概括
这项案例研究强调了一名患者在感染严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 后不久就出现了皮肤肌肉炎 (DM),这表明病毒感染可能会引发自身免疫性疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致COVID-19,主要是呼吸系统症状.
- 肺外表现,包括神经复杂症,可发生在COVID-19患者.
- COVID-19和皮肤肌肉炎 (DM) 病原体之间的联系尚未得到充分证实.
研究的目的:
- 报告以前健康的个体在感染SARS-CoV-2后出现了DM症状的病例.
- 为了调查COVID-19和DM的开始之间的潜在关联.
主要方法:
- 一名37岁的男性士兵患有COVID-19和随后的DM症状的病例报告.
- 临床表现包括咳,发烧,疲劳,皮肤和肌肉表现.
- 实验室测试显示,肌酸激酶 (CK) 水平升高,抗Mi-2自身抗体呈阳性,在电诊断测试中出现肌病.
主要成果:
- 患者在COVID-19发病四天后出现了经典的DM症状 (皮肤和肌肉).
- 肌肉酶的显著升高 (CK 8253 U/l) 和肌肉炎特异性自身抗体 (抗Mi-2) 的存在.
- 电子诊断测试证实了肌肉病变,与临床发现一致.
结论:
- 虽然确切的相关性尚不清楚,但SARS-CoV-2感染可能会成为DM等自身免疫性疾病的触发因素.
- 这一案例强调了病毒感染可能导致多系统自身免疫性疾病的可能性.
- 需要进一步的研究来阐明将COVID-19和自身免疫性疾病联系在一起的机制.
相关概念视频
Myocarditis II: Clinical Features and Diagnostic Tests
12
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
12
Skin Diseases and Disorders
3.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K
Immunodeficiency Diseases
1.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.0K
Rous Sarcoma Virus (RSV) and Cancer
5.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.2K
Autoimmune Disorders
529
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
529
Myocarditis I: Introduction
10
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
10


