非编码RNA在软骨末板中的作用 (综述)
Xiaokun Zhao1, Jinghong Yuan1, Jingyu Jia1
1Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Experimental and therapeutic medicine
|June 5, 2023
概括
非编码RNAs (ncRNAs) 在软骨末板 (CEP) 退化中发挥着至关重要的作用,这是椎间盘退化的关键驱动因素. 了解ncRNA调节为IDD提供了新的治疗途径.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 软骨端板 (CEP) 退化是椎间盘退化的主要原因,导致广泛的部和腰部疼痛.
- 非编码RNAs (ncRNAs),包括长ncRNAs,microRNAs和圆形RNAs,涉及到各种疾病过程.
- 在CEP中ncRNAs的特定参与和功能在很大程度上仍未被探索.
研究的目的:
- 审查关于ncRNA相互作用和CEP中的监管作用的当前研究.
- 概述IDD中已知的ncRNAs放松调节及其对CEP细胞功能的影响.
- 提供有关IDD病原体的见解以及针对ncRNAs的潜在治疗策略.
主要方法:
- 在CEP和IDD中调查ncRNA的研究的文献综述.
- 综合现有关于ncRNA调节CEP细胞功能的知识.
- 在IDD病原性背景下对ncRNA放松调节的分析.
主要成果:
- ncRNA是信号通路和生物过程的关键调节者,对CEP健康至关重要.
- 对ncRNAs的失调有助于CEP细胞功能障碍,包括改变的增殖,亡和细胞外基质代谢.
- 通过它们对CEP细胞的影响,特定的ncRNA被确定为IDD发展的关键参与者.
结论:
- ncRNAs是CEP健康和疾病的组成部分,其调节失调显著导致IDD.
- 在CEP中理解ncRNA机制为IDD的新型治疗干预提供了有希望的目标.
- 本综述强调了ncRNAs在IDD病原和未来研究方向中的重要性.
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