帕奇米酸调节sirtuin 6的活性,以缓解脂质代谢障碍
Zhi-Sen Pan1,2, Yan-Ling Chen2, Kai-Jia Tang3
1Department of Traditional Chinese Medicine, The First People's Hospital of Kashgar Prefecture, Kashgar, Xinjiang Uyghur Autonomous Region 844000, P.R. China.
Experimental and therapeutic medicine
|June 5, 2023
概括
来自Poria cocos的帕奇米酸激活了Sirtuin 6 (SIRT6) 信号,改善了小鼠肝细胞中的脂质代谢障碍. 这种激活减少了甘油三的积累,并增强了脂肪酸的氧化.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 波利亚可可斯含有生物活性化合物,包括帕奇米酸 (Pac),以抗氧化特性和抑制甘油三 (TG) 积累而闻名.
- 肝细胞中的脂质代谢障碍是一个重大的健康问题,通常与饮食和代谢功能障碍有关.
研究的目的:
- 为了调查帕奇米酸 (Pac) 是否激活sirtuin 6 (SIRT6) 信号,以缓解小鼠初级肝细胞 (MPH) 中油酸 (OA) 和棕酸 (PA) 诱导的脂质代谢障碍.
- 通过SIRT6.6阐明Pac对脂质代谢作用的潜在机制.
主要方法:
- 鼠标初级肝细胞 (MPH) 用Pac治疗,并用OA + PA挑战,以评估细胞内脂质代谢.
- 分子对接被用来识别Pac的潜在目标.
- 来自肝脏特异性SIRT6缺乏的小鼠的MPH被用来确定SIRT6在Pac影响中的作用.
- 测量了TG积累和脂肪酸氧化率.
主要成果:
- 在MPH患者中,Pac治疗增加了SIRT6表达和脱乙酶活性.
- 在OA + PA化MPH中,Pac显著降低了TG积累,并以剂量依赖的方式增强了脂肪酸氧化.
- 缺少SIRT6消除了Pac对OA + PA诱导的脂质代谢障碍的保护作用,证实了SIRT6的关键作用.
结论:
- 帕奇米酸通过激活SIRT6信号来缓解OA + PA诱导的肝细胞脂质代谢障碍.
- 通过Pac激活SIRT6有助于增加氧化应激并促进肝细胞脂解,为代谢障碍提供潜在的治疗策略.
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