开发和可行性测试的综合性PTSD和坚持干预认知处理治疗-生活步骤 (CPT-L) 改善艾滋病毒的结果:试验协议
Cristina M Lopez1, Nathaniel L Baker2, Angela D Moreland1
1Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Contemporary clinical trials communications
|June 5, 2023
概括
这项研究测试了艾滋病毒感染者治疗创伤后应激障碍 (PTSD) 和抗逆转录病毒疗法 (ART) 的综合治疗方法. 综合方法在改善创伤后应激障碍症状和艾滋病毒治疗结果方面表现有希望.
科学领域:
- 心理健康 心理健康
- 传染性疾病 传染性疾病
- 临床心理学 临床心理学
背景情况:
- 创伤后应激障碍 (PTSD) 的高发病率会对艾滋病毒的健康结果产生负面影响.
- 避免性行为,PTSD症状,与艾滋病毒感染者 (PLWH) 抗逆转录病毒疗法 (ART) 坚持不佳有关.
- 现有的基于证据的PTSD治疗方法尚未评估它们对PLWHHIV结果的影响.
研究的目的:
- 测试综合性PTSD治疗 (认知处理疗法 - CPT) 和PLWH的坚持干预 (Lifesteps) 的可行性和可接受性.
- 评估修改后的CPT协议 (CPT-Lifesteps) 对PTSD症状和HIV治疗结果 (ART坚持,病毒抑制,在护理中保留) 的影响.
- 探索PTSD治疗作为一种新的策略,以减少ART坚持的障碍,并改善艾滋病毒治疗.
主要方法:
- 一个试点的开放标签随机对照试验 (RCT) 涉及PLWH与同时发生的PTSD.
- 使用小队列 (n=12) 进行可行性和可接受性测试.
- 一个更大的试验 (n=60) 将集成CPT-Lifesteps干预与Lifesteps加标准护理进行比较.
主要成果:
- 该研究旨在评估综合干预的可行性,可接受性和影响.
- 测量的主要结果将是PTSD症状严重程度的变化和与艾滋病毒相关的健康结果.
- 二次结果将包括对ART的坚持和在HIV护理中保持.
结论:
- 这项研究开创了基于证据的PTSD治疗在艾滋病毒护理环境中的整合.
- 这些发现预计将通过改善病毒抑制来支持无可检测=无可传播 (U=U) 运动.
- 这项研究旨在建立一个新的范式,以解决ART遵守的障碍,并改善PLWH的健康结果.
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